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Deoxyribose Nucleic Acid and Ribose Nucleic Acid

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Deoxyribose Nucleic Acid and Ribose Nucleic Acid
DNA stands for Deoxyribose Nucleic Acid while RNA stands for Ribose Nucleic Acid. Compounds of Carbon, Hydrogen, Oxygen, Nitrogen and Phosphorus. Made up of Nucleotide Monomers (Polynucleotides). A nucleotide consists of a Nitrogenous base, a Pentose Sugar & Phosphate Group.
Nucleoside: Nitrogenous Base + Sugar.
5 Nitrogenous Bases are there :
  1. Cytosine
  2. Uracil
  3. Thymine
  4. Adenine
  5. Guanine

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Cytosine, Uracil, and Thymine are the Pyrimidine Derivatives with a single ring structure.
Adenine and Guanine are the Purine Derivatives with a double ring structure.
The pentose sugars are of 2 types:
  • Deoxyribose
  • Ribose
Thus, the Nitrogenous bases, combining with Pentose Sugars and a Phosphate Group, form 8 type of Nucleotide Molecules :

  • Cytosine + Ribose Sugar + Phosphate
  • Cytosine + Deoxyribose Sugar + Phosphate
  • Uracil + Ribose Sugar + Phosphate
  • Thymine + Deoxyribose Sugar + Phosphate
  • Adenine + Ribose Sugar + Phosphate
  • Adenine + Deoxyribose Sugar + Phosphate
  • Guanine + Ribose Sugar + Phosphate
  • Guanine + Deoxyribose Sugar + Phosphate
Deoxyribose Nucleic Acid Molecule
Long and highly complex, spirally twisted, right-handed double helix, Ladder like structure formed by 2 polynucleotides strands. Base thymine is present, but never uracil. Wilkins, Watson and Crick (1953) received Noble Prize for Deoxyribose Nucleic Acid Structure. Adenine links with Thymine by two hydrogen bonds. Guanine with cytosine by three hydrogen bonds. A single Deoxyribose Nucleic Acid molecule has millions of pairs of nucleotide monomers. Deoxyribose Nucleic Acid contains “Blue Print” of life. With RNA’s help, it directs the synthesis of all structural and functional proteins of Protoplasm.
Difference Table of DNA and RNA
DNA RNA
It usually occurs inside nucleus and some cell organelles. Very little RNA occurs inside nucleus. Most of it is found in the cytoplasm.
DNA is the genetic material. RNA is not the genetic material except in certain viruses. e.g., TNIV, Reovirus.
It is double stranded with the exception of some viruses. RNA is single stranded with the exception of some viruses (e.g., double stranded in Reovirus).
DNA shows regular helical coiling. There is no regular coiling except in parts of RNA.
DNA forms chromosomes of similar structures. rRNA forms ribosomes.
DNA contains several million nucleotides. Depending upon the type, RNA contains 10-12000 nucleotides.
DNA is of only two types, nuclear and extra nuclear. There are at least three types of RNA-rRNA, mRNA and tRNA
It contains deoxyribose sugar. It contains ribose sugar.
Nitrogen base thymine occurs in DNA along with three other-adenine, cytosine and guanine. Thymine is replaced by uracil in RNA. The other three are adenine, cytosine and guanine.
Renaturation after melting is slow. It is quite fast.
Hydrogen bonds tire formed between complementary nitrogen bases of the opposite strands of DNA (A : T, C : G) Base pairing through hydrogen bonds occurs only in the coiled parts.
DNA RNA
It replicates to form new DNA molecules. It cannot replicate itself except in RNA-RNA viruses.
DNA transcribes genetic information to RNA. RNA translates the transcribed message for forming polypeptides.
DNA controls heredity, evolution, metabolism, structure and differentiation. RNA controls only protein synthesis.
Its quantity is fixed for cell. The quantity of RNA of a cell is variable.
DNA controls metabolism and genetics including variations. It only controls metabolism under instructions from DNA.
Purine and pyrimidine bases are in equal number. There is no proportionality between number of purine and pyrimidine bases.
It can be hydrolyzed by enzyme DNA-ase. RNA is hydrolyzed by RNA-ase.

 

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Story of Hydrogen Bomb Development

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hydrogen bomb development story

In 2016 North Korea claimed the Hydrogen Bomb Development by their scientists and its successful test and left entire world shocked and terrorised.

Later Observers also confirmed that a nuclear explosion has taken place which must be bigger than that of the last test in 2013, but not nearly big enough to be a full thermonuclear explosion – an “H-bomb” – as Pyongyang claims. But in contemporary research they cleared and agreed that a part of thermonuclear device has been tested by North Korea.

Hydrogen Bomb Development

All this started with the decision of Harry S. Truman, the American President to fund and support the development of a weapon theorized to be hundreds of times more powerful than the nuclear bomb dropped on Japan. This decision was taken on 31st January, 1950.

This was beginning of the race to build a Super bomb among super powers.

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What was the need of a new bomb as US already had deadly nuclear weapon?

The decision of Hydrogen Bomb Development in US came five months after Soviet Union snatched away the nuclear supremacy of US by successfully detonating an Atomic Bomb in Kazakhstan.

US intelligence concluded that Klaus Fuchs, a German-born scientist of top ranks who was involved in the US nuclear weapon development program (Manhattan Project) turned out to be a Soviet spy. He was alleged for transferring all the knowledge that US had about nuclear bomb to Soviet Union.

This incident forced United States to give massive fund to another program for development of super bomb and reclaim its supremacy in war weapons.

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Detonated the first Hydrogen Bomb?

United States, on 1st November 1952, around three years after the announcement it detonated first Hydrogen Bomb ‘Mike’.

Mike was a 10.4 megaton thermonuclear device built upon the Teller-Ulam Principle of Stage Radiation Implosion.

This bomb instantly vaporized the entire island leaving behind a more than mile wide crater only. A mushroom cloud of 1,20,000 feet high ceiling, 60 miles across stretch was formed in few minutes.

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Who was next to detonate H-Bomb?

Of course Soviet Union, three years later on 22 Nov, 1955 detonated its first Hydrogen bomb which was working on the same principle of Radiation Explosion.

The detonation by Soviet Union defeated the purpose of hydrogen bomb development by US, and today it has gone into the hands of a country which is not counted among responsible nation by rest of the world.

hydrogen bomb process
Hydrogen Bomb Process

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Today in History – 4 February

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1628

Shah Jahan was enthroned and proclaimed emperor at Agra.

Shahabuddin Muhammad Shah Jahan (15 January 1592 – 31 January 1666) was the fifth Mughal Emperor of India from 1628 to 1658. Born Prince Khurram, he was the son of Emperor Jahangir and his Hindu Rajput wife, Taj Bibi Bilqis Makani.

He was chosen as successor to the throne after the death of his father in 1627. He was considered one of the greatest Mughals of the Timur family. Like his grandfather, Akbar, he was eager to expand his vast empire. In 1658, he fell ill and was confined by his son and successor Aurangzeb in Agra Fort until his death in 1666.

1757

Lord Clive remained unsuccessful after sending two ambassadors to make treaty with Siraj -Ud -Daula, while he was marching towards Calcutta.

1910

New Press Censorship bill announced, British government say repressive measures necessary to halt unrest.

1924

Mahatma Gandhi released from prison unconditionally at Bombay.

1944

Japanese attack Indian Seventh Army at Burma.

1948

Rashtriya Swayamsevak Sangh (RSS) banned.

Finance Minister announces nationalisation of the Reserve Bank of India (RBI) after Sept 30, 1948.

1978

Satyendra Nath Bose, a noted mathematician, professor and physicist, passed away at Calcutta. He contributed greatly to statictical mechanics, the electromagnetic properties of ionosphere, the theories of X-ray crystallography and thermoluminescence, and unified field theory. Bose instituted “Planck’s Law and the Hypothesis of Light Quana”. He died on this day.

1990

Ernakulam was declared the first totally literate district in India.

1994

India elected to the executive boards of UNDP, UN Population Fund and UNICEF.

Today in History – 3 February

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1760

Sadashiv Bhau, under a large Maratha army, defeated the Nizam in War of Udgir.

Bhau was the nephew of Peshwa Baji Rao I, He played an important role in the third battle of Panipat He was the Sarsenapati of the Maratha Army. In the same battle of Panipat, he died fighting. He was the son of Chimaji Appa and Rakhmabai.

1916

Banaras Hindu University was opened under the guidance of Madan Mohan Malaviya in Varanasi, Uttar Pradesh.

It is still one of the largest residential universities in Asia with a strength of over 20,000 students. BHU is a public central university.

1925

First Electric Train started its journey from Bombay V. T. (presently known as C.S.T.) to Kurla. This train was on the Central Railway, Bombay.

The train was electrified on 1500 Volt DC. Later the electric line was first extended to Nasik’s Lagatpuri and then to Puna. Till Indian independence in 1947 around 388 km of Railway was electrified in the country.

1928

Simon Commission comes to India under Lord Irwin, after which serious rioting started on his arrival.

1988

INS Chakra was inducted into the Indian Navy when the first Soviet SSN Victor 1 class nuclear-propelled submarine and India joined the maritime nuclear powers.

1994

Akash missile launched successfully. It is a medium-range mobile surface-to-air missile defense system developed by the Defence Research and Development Organisation (DRDO), Bharat Dynamics Limited (BDL) for Missile Systems, Ordnance Factories Board and Bharat Electronics (BEL).

1995

The Transplantation of Human Organs Act, notified after 7 months of Presidential assent, becomes enforceable.

Kumbh Mela

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kumbh mela

India is a land of fairs and festivals and one such fair that attracts a number of people from around the world is Kumbha mela. The cultural tradition of India has always given a religious significance to all the river systems and so does the kumbha mela. It is originated by the river sides at the four different places which are Haridwar, Allahabad, Nasik and Ujjain. The Ganga flows through Haridwar. Allahabad is at the confluence of the Ganga, the Yamuna and the mythological river Saraswati. The Godawari and the Shipra flows through Nasik and Ujjain respectively. The place to organise Kumbh mela  is chosen from the ones mentioned above on a rotational basis.

Kumbh mela finds its mention in Bhagvat Purana, Vishnu Purana, the Ramayana and the Mahabharata. The legend says that there occurred a tussle between the Devas and the Asuras over an urn, called kumbha in sanskrit, which contained the nectar churned out of sea. Nectar was supposed to provide immorality to the one who would have it and therefore called ‘amrit’ and the process of churning it out was known as ‘amrit manthan’. During the tussle Lord Vishnu flew away with the urn and a few droplets of nectar fell over the grounds of Haridwar, Allahabad (prayag), Nasik and Ujjain and this is the reason why these places have been chosen to organise Kumbha mela. People believe that due to the presence of this nectar, there sins get washed away when they visit these places and take a dip in the holy river.Kumbh Mela

‘Kumbha’ mela is called as the largest religious congregation of the world as millions of people from around the globe take part in it whenever it is held. Kumbha mela is ideally held every 3 years at a different place but the exact time and place of the festival depends upon astrological and religious considerations and that is why sometimes it can happen before the three year interval time period. ‘Maha kumbh’ mela is held once every 12 years. It occurs only at Allahabad and is considered the most auspicious out of the three categories of mela. The third category is of ‘Ardha kumbha’ mela and it takes place once in 6 years and it occurs at both Allahabad and Haridwar. The 2015 editon of kumbha mela is going on in the nasik district of Maharashtra. It started on 14th July 2015 and will conclude on 25rd september 2015. The day of mauni amavasya is considered to be the most auspicious day to take the holy dip and therefore it attracts a huge number of crowd.

There are various kind of sadhus who take part in the kumbh mela. Naga sadhus remain naked and smear their bodies with ash. Urdhwavahurs are the ones who have emaciated their bodies due to rigid spiritual practices. Parivajakas is the name given to the ones who have taken an oath of silence. Sadhus who remain in a standing position and meditate while standing on their heads are called Shirshasinse. Kalpvasis always remain by the river side meditating and devoting their time and life to rituals and holy bathing.

Also Read: Events and Festivals in Puri